ZNF582-AS1 overexpression inhibits cell proliferative, migratory and invasive ability and promotes cell apoptosis in ccRCC through suppressing the N(6)-methyladenosine modification of MT-RNR1, resulting in the decrease of MT-RNR1 expression, followed by the decrease of MT-CO2 protein. Here, ZNF582 is linked to nonpapillary renal cell carcinoma.