ZNF582 and nonpapillary renal cell carcinoma: Based on TCGA-KIRC RNA-seq and clinical data, ZNF582-AS1 expression was downregulated in ccRCC tissues compared with in the adjacent normal renal tissues (Fig. 1a), and lower ZNF582-AS1 expression was associated with advanced tumor stage, higher pathological stage, distant metastasis, and shorter OS (Overall Survival) and DFS (Disease Free Survival) (Fig. 1b).