As shown in Fig. 10, ZNF582-AS1 overexpression suppresses the N(6)-methyladenosine modification of MT-RNR1 by reducing A8K0B9 protein level, resulting in the decrease of MT-RNR1 and MT-CO2 expression and subsequently phenotype inhibition of ccRCC cells, thus playing the role of tumor suppressor gene in ccRCC pathogenesis. Here, ZNF582 is linked to nonpapillary renal cell carcinoma.