STAT3 and colorectal carcinoma: Indeed, KRASMUT can upregulate anti apoptotic Bcl-xL expression in CRC cell lines (KRASG12V and KRASG13D) with a suggested role of ERK [155] or signal transducer and activators of transcription 3 (STAT3) transcription factor [156] in mediating Bcl-xL upregulation by KRASMUT.