Among 66 children with early-onset of IBD there were identified 16 (24.2%) with mutations in Il-10-related genes including 8 (12.1%) with mutation in Il-10RB gene, 5 (7.6%) with mutation in Il-10RA gene and 3 (4.5%) with mutation in Il-10 gene [30]. Here, IL10RA is linked to inflammatory bowel disease.