IGFBP3 and type 2 diabetes mellitus: Of the 13 proteins identified as DEPs in patients with T2DM + LAC by SWATH-MS analysis, 7 proteins showed significant dysregulation between T2DM + LAC and T2DM, including CCD87, FHR1, FRPD2, HBB, IGFBP3, PZP, and ZN350 (Table 5).