When compared with those with normal BMD and osteopenia, T2DM patients with osteoporosis had significantly more female subjects, older age, larger proportions of stroke and PAD, higher NLR and BNP, and lower height, weight, lymphocyte count, Hb, ABI, calcium, OSTA, BMD at different skeletal sites and corresponding T scores (P < 0.01 or P < 0.05; Table 1 and Fig.1). The gene discussed is NPPB; the disease is osteoporosis.