In agreement with previous studies, we found that T2DM patients with osteoporosis had significantly higher circulating BNP, and circulating BNP was correlated positively with the prevalence of osteoporosis, and negatively with BMD at different skeletal sites and corresponding T scores, and OSTA, which could be used conservatively to identify individuals who are likely to have low BMD and classify the risk of osteoporosis [21]. Here, NPPB is linked to osteoporosis.