There were significant differences in anthropometric parameters (gender distribution, age, height, and weight), biomarkers of inflammation (lymphocyte count, NLR and Hb), prevalence of vascular diseases (stroke, PAD, and DN) and related indexes (PP, eGFR, ABI, and VPT), bone metabolism markers (calcium, ALP, and OSTA), BMD at different skeletal sites and corresponding T score, and prevalence of clinical fractures among three groups. The gene discussed is GSTM1; the disease is Stroke.