On the other hand, among the four subgroups composed according to IgE sensitization, the hazard of recurrent CVA in children with CHD along with IgE sensitization was highest (P = 0.000, log-rank test, see Fig. 5), but there was no significant interaction between CHD and IgE sensitization in relation to the hazard of recurrent CVA (P for interaction = 0.414, see Fig. 3). This evidence concerns the gene IGHE and coronary artery disorder.