ACP5 and colorectal carcinoma: Meanwhile, the mRNA levels of Cathepsin K and TRAP were downregulated in miR-325-3p overexpressed group and upregulated in miR-325-3p inhibited group (Fig. 2d, e), Together, these results indicated miR-325-3p can inhibit the enhanced osteoclastogenesis caused by secreta of CRC cells.