Patients receiving other nephrotoxic medications (ACE inhibitors, loop diuretics, antiretroviral therapy, or chemotherapy agents) were more likely to experience a significant rise in creatinine during amikacin treatment, and less likely to have recovery of renal function by the end of MDR-TB treatment (86% of patients not receiving other nephrotoxic medications had recovery of renal function vs. 40% of patients receiving nephrotoxic medications in addition to amikacin; p = 0.043). Here, ACE is linked to tuberculosis.