The activation of STAT3 in renal glomerular and mesangial cells the increased the production of TGF-β1, collagen IV, and fibronectin, resulting in glomerulosclerosis in DN (Chuang and He 2010; Lu et al. 2009; Bienaime et al. 2016). This evidence concerns the gene TGFB1 and glomerulosclerosis.