Gene expression analysis on breast cancer tissue of 35 out 222 patients (N = 4 with CNV > 2 and N = 31 with CNV = 2 in blood) (Table 3) has revealed a positive and statistically significant correlation between E2F1 expression and number of copies (p = 0.004) (Fig. 1a). The gene discussed is E2F1; the disease is breast carcinoma.