E2F1 and melanoma: Interestingly, we found that the frequency of CNVs of E2F1 was higher in the patients compared to controls (4.5%), suggesting therefore that altered CNVs of E2F1 may play a key role as predisposing factor of BC as well as it was reported in patients with testicular cancer and melanoma (Rocca et al. 2017; Rocca et al. 2019).