LDLR and homozygous familial hypercholesterolemia: EL overexpression was associated with a decrease in total and non-HDL-C levels in several mouse models, including ldlr KO mice.18 Interestingly, overexpression of EL was also associated with faster LDL particle clearance in ldlr KO mice,18 suggesting that the increase in LDL apoB catabolism observed during treatment with evinacumab in the 4 patients with hoFH could be mediated, at least in part, by an increase in EL activity.