TRPM7 forms a unique ion channel that contains a kinase domain in its C-terminal region.42 The TRPM7 channel is highly permeable to Ca2+ and Mg2+ and contributes to vascular remodeling by promoting inflammation, fibrosis, cell migration and cell proliferation.21 Such effects appear to underlie the significance of TRPM7 in the pathogenesis of PAH. The gene discussed is TRPM7; the disease is pulmonary arterial hypertension.