These inhibitory effects were consistent with those observed with either the siRNA-mediated knockdown of TRPM7 or treatment with FTY-720, which is known to inhibit TRPM7 activity.40 Moreover, the genetic knockout of TRPM7 ameliorated the development of pulmonary hypertension and vascular remodeling in MCTp-induced PH mice. Here, TRPM7 is linked to pulmonary arterial hypertension.