Deficiency of intracellular Mg2+, in part due to TRPM7 dysfunction, has been shown to be associated with hypertension.48 Furthermore, the activation of Gq protein-coupled receptors has been shown to attenuate TRPM7 activity by activating the phospholipase C and facilitating the hydrolysis of phosphatidylinositol 4,5-bisphosphate.49 Vasoconstrictors, such as angiotensin II and endothelin-1, could suppress TRPM7 activity. The gene discussed is EDN1; the disease is hypertensive disorder.