STAT3 and pulmonary arterial hypertension: The involvement of TRPM7 in the phosphorylation of STAT3 and Akt was investigated in HAPECs and HPASMCs, as the activation of STAT3 and Akt signaling has been reported to be involved in the vascular remodeling associated with PAH.27,41 The siRNA-mediated knockdown of TRPM7 reduced the basal phosphorylation level of STAT3 in HPASMCs (Fig 6A).