Importantly, although T cells present in severe influenza infection and during recovery maintained elevated VDAC1 and H3K27me3 expression, clustering the H3K27me3hiVDAC1hi CD4 T cells by protein expression of all other markers included in the flow cytometry panel showed that these cells robustly clustered based on disease type, indicating qualitative differences in H3K27me3hiVDAC1hi T cells across disease status (Figure 2F). This evidence concerns the gene CD4 and influenza.