H3K27me3 is regulated in part by α-ketoglutarate-mediated jumonji demethylases (Pearce and Shen, 2006), while VDAC1 is a mitochondrial membrane protein involved in metabolite transport and has been associated with mitochondrial cell death signaling and lupus-like autoimmunity (Ben-Hail et al., 2016; Kim et al., 2019). The gene discussed is VDAC1; the disease is Autoimmunity.