Two of these eGenes, GSTM3 (FDR = 0.014) and HSPA6 (FDR = 0.029), have been associated to disease traits such as Hepatitis B (HBV) for GSTM3 and Hepatocellular Carcinoma (HCC) for both eGenes.26–29 African Americans have a higher incidence and worse outcomes of HBV and HCC when compared to other demographics.30, 31 Since these eGenes were not significant with PC-adjusted eQTL mapping, they may explain how methylation plays a role in the health disparities observed in African Americans. The gene discussed is GSTM3; the disease is hepatocellular carcinoma.