The top-ranked gene-cancer pairs with truncations include the MET proto-oncogene from brain lower grade glioma (LGG), the calcium channel gene CACNA1A from lung adenocarcinoma (LUAD), and TP53 from BRCA; the top-ranked gene-cancer pairs with missense mutations include JAK2 from stomach adenocarcinoma (STAD), TP53 from lung squamous cell carcinoma (LUSC), and FGFR3 from bladder urothelial carcinoma (BLCA). Here, CACNA1A is linked to bladder transitional cell carcinoma.