The top-ranked gene-cancer pairs with truncations include the MET proto-oncogene from brain lower grade glioma (LGG), the calcium channel gene CACNA1A from lung adenocarcinoma (LUAD), and TP53 from BRCA; the top-ranked gene-cancer pairs with missense mutations include JAK2 from stomach adenocarcinoma (STAD), TP53 from lung squamous cell carcinoma (LUSC), and FGFR3 from bladder urothelial carcinoma (BLCA). The gene discussed is FGFR3; the disease is bladder transitional cell carcinoma.