Of note, the levels of phosphorylation of IRF3 and IRF7 in U937 cells infected with m6A-deficient HIV-1 were 2.6- and 3.1-fold higher than those in mock infection, and 1.6- to 1.7-fold higher compared to cells infected with control HIV-1 (Fig 3F). This evidence concerns the gene IRF3 and infection.