Several proteins have been expressed significantly different during metformin treatment and hyperinsulinemia, of which AMFR, CCND2, CD63, CEACAM8, CTSL, GFAP, GUSB, IRF4, PI3, PLCG2, SORL1, TFRC, VEGFA, VTCN1, and WNT2B have already been discussed above. This evidence concerns the gene SORL1 and hyperinsulinism.