In contrast, the following proteins were regulated in a more favorable way during hyperinsulinemia compared to a treatment with metformin: coagulation factor III (F3, tissue factor (TF)), galectin-1 (LGALS1, LEG1), 5’-nucleotidase ecto (NT5E, 5NTD), and plasminogen activator urokinase receptor (PLAUR, UPAR). Here, NT5E is linked to hyperinsulinism.