SOCS1 and methicillin-resistant staphylococcus aureus infectious disease: However, while iKIR plus IgG control decreased bacterial load, the treatment of mice with anti-IFNGR antibody did not prevent iKIR effects on bacterial clearance, demonstrating that IFNγ is not solely involved in the inhibitory effects of SOCS-1 during MRSA skin infection (Fig 4B).