MDM2 and liposarcoma: In case of liposarcomas, several studies on their genome landscapes have been done, but mainly two characteristic molecular markers are known, amplification of the 12q13-15 region (including MDM2, FRS2 and usually also CDK4), which is detected in almost all WDLPS or DDLPS, and the fusion oncogenes FUS-DDIT3 or EWSR1–DDIT3 in myxoid and round cell liposarcoma.