Examples include BRD2 [18], which binds to IL-6 promoters in macrophages where it stimulates IL-6 production, PLEKHO1, which regulates joint inflammation [19] and BACH2 [20–22] and DOCK2 [23, 24] which are important in B cell differentiation and T cell regulation, both important events in the development of early RA. This evidence concerns the gene PLEKHO1 and rheumatoid arthritis.