CD8A and diabetes mellitus: FABP4+/+NOD mice transplanted with FABP4–/– BM exhibited much lower incidence of diabetes than FABP4+/+NOD mice transplanted with FABP4+/+ BM (57.38% vs. 83.91%) (Figure 7B), accompanied with significant reductions in insulitis (Figure 7C), β cell apoptosis (Figure 7, D and E), proinflammatory macrophages (Figure 7, F and G), autoreactive CD8+ T cells, Th1, and Th17, but increased frequencies of Th2 and Tregs (Figure 7, H and I).