To explore whether FABP4 influences the development of autoimmune diabetes via its actions in diabetogenic T cells, we isolated CFSE-labeled CD4+ T or CD8+ T cells from FABP4–/–NOD and FABP4+/+NOD mice and adoptively transferred these diabetogenic T cells into FABP4–/–NOD mice, followed by monitoring diabetes incidence in recipient mice (Supplemental Figure 6, A–C). This evidence concerns the gene CD4 and diabetes mellitus.