Leaving out sequence complementarity, we constructed the co-expression networks of all HF/DE-mRNAs, DE-miRs, and DE-lncRNAs (|Pearson r| > 0.8 and P < 0.05), including a positive co-network (Supplementary Figure 3A, Pearson r > 0.8 for all nodes) and a negative co-expression network (Supplementary Figure 3B, Pearson r < -0.8 for all nodes); the hub genes in the 2 networks were SERPINC1 and PKM, respectively. The gene discussed is PKM; the disease is hydrops fetalis.