In the murine model SOD1-G93A that mimics amyotrophic lateral sclerosis (ALS), which causes skeletal muscle fibrosis, the treatment with AM095, an LPA1 inhibitor, causes motor skills improvement evaluated by grip strength, rotarod, and runtime (Gento-Caro et al. 2021). Here, LPAR1 is linked to amyotrophic lateral sclerosis.