ENPP2 and pulmonary fibrosis: According to the evidence summarized in this review, many investigations show promising effects of pharmacological inhibitors of the ATX/LPA/LPARs axis in murine models of kidney, skin, and lung fibrosis (Gan et al. 2011; Ohashi and Yamamoto 2015; Pradere et al. 2008; Castelino et al. 2011; Ninou et al. 2018).