Ingenuity pathway analysis (IPA) identified cardiac hypertrophy-associated genes, such as peroxisome proliferator-activated receptor gamma coactivator 1 alpha (Ppargc1a), Elastin (Eln), angiotensin-I-converting enzyme (Ace), 5’-nucleotidase (Nt5e), cyclin-dependent kinase inhibitor 1A (Cdkn1a), chemerin chemokine-like receptor 1 (Cmklr1), and A-kinase anchor protein 5 (Akap5) gene was differentially expressed in the hearts of vehicle-treated NSML mice compared to vehicle-treated WT mice (Fig. 6g). The gene discussed is ACE; the disease is cardiac hypertrophy.