Compared with the group without anti-PD-L1 antibody, the apoptosis rate of containing anti-PD-L1 antibody group was significantly decreased, the same results were observed in MDA-MB-231, T47D, MCF-7, MDA-MB-453 breast cancer cell lines (p < 0.001 all in Fig. 8a–e). This evidence concerns the gene CD274 and breast cancer.