Significantly, high expression of PD-L1 in tumor tissue is valuable, as is that of sPD-L1, a soluble form of PD-L1 in blood measured by enzyme-linked immunosorbent assay (ELISA) [18], which is a potential prognostic predictor in certain hematological malignancies and solid tumors [19–22]. This evidence concerns the gene SPDL1 and neoplasm.