Recent studies in mouse retinae [133, 134] and zebrafish non-cerebral vessels [135, 136] show that Endoglin plays a crucial role in mouse retinal angiogenesis [133] and is also implicated in hereditary haemorrhagic telangiectasia (HHT) which may cause cerebral cerebrovascular arteriovenous malformations with upregulation of VEGF signalling [133, 134]. The gene discussed is ENG; the disease is hereditary hemorrhagic telangiectasia.