Firstly, today we know from earlier data that in NAFLD patients there is an increased production of various proinflammatory cytokines, for example, interleukin-1 (IL-1), interleukin-6 (IL-6), TNF-alfa, TGF-beta, plasminogen activator inhibitor-1, increased reactive oxygen species, etc. These cytokines are produced by hepatocytes and non-parenchymal cells (Kupffer cells and hepatic stellate cells) [25–27]. Here, SERPINE1 is linked to metabolic dysfunction-associated steatotic liver disease.