H6PD and Alzheimer disease: In addition, findings relative to increased glucose 6-phosphate dehydrogenase (G6PDH) in AD and PD [44, 45] and increased thioredoxin reductase (TrxR) [46], neuronal thiols, and GSH/GSSG ratio in AD [44, 47] suggest that reductive reprogramming has an important role in these disorders.