It has been found that [47] the level of Drpl protein in the cytoplasm of mouse cardiomyocytes and its phosphorylated protein levels were decreased, while the level of Drp1 protein in the mitochondrial outer membrane was increased, which indicates that the level of miR-499 can affect the degree of apoptosis and myocardial infarction. The gene discussed is DNM1L; the disease is myocardial infarction.