In a recent study, heart failure was induced by ascending aorta cerclage in wild-type mice, followed by treatment using Drp1 inhibitor mdivi-1, which showed that mdivi-1 treatment alleviated left ventricular dysfunction, and these effects were considered to be associated with reduced expression of the autophagy markers LC3 and p62 [62]. The gene discussed is DNM1L; the disease is heart failure.