Because traditional TAA markers, such as cytokeratin 19 fragment antigen (CYFRA21-1), neuron-specific enolase (NSE), carcinoembryonic antigen (CEA), and squamous cell carcinoma antigen (SCC), remain widely used as reference diagnostics for lung cancer [37], we compared the 7-AAB panel with the combination of these traditional TAAs in the diagnosis of LC. This evidence concerns the gene SERPINB3 and laryngotracheoesophageal cleft.