Our review previously meta-analyzed four studies that measured the EarlyCDT-Lung Test 7-AAB panel (p53, CAGE, NYESO-1, GBU4-5, SOX2, MAGE A4, and Hu-D), showing a sensitivity of 47% (95% CI 0.34–0.60) with a high specificity of 90% (95% CI 0.87–0.93) in the early detection of lung cancer [19, 21, 33, 34, 35]. This evidence concerns the gene SOX2 and lung cancer.