Keeping in terms of osteogenic differentiation, hAECs, cultured in OM and stimulated with pulsed electromagnetic fields (PEMFs), increased ALP, BMP2, RUNX2, nuclear factor erythroid 2-related factor 2 (NRF2), Kelch-like ECH-associated protein 1 (KEAP1) and OCN gene expression, ALP activity, and OCN protein and calcium deposition in comparison to cells in NM or in OM, without PEMFs, after 3, 7, 11, and 21 days. The gene discussed is KEAP1; the disease is ocular melanoma.