Preliminary in vitro data showed no effect of irisin treatment in the colon, thyroid, esophageal, and endometrial cancer cell lines [27], while later data supported potential anticarcinogenic properties of irisin in malignant breast [15], lung [28], osteosarcoma [29], and pancreatic [30] cancer cell lines. The gene discussed is FNDC5; the disease is endometrial cancer.