Similar results were observed when cancer-free individuals were compared to the recently identified treatment-naïve cancer group, i.e., for age (OR = 1.04, 95% CI = (1.01, 1.08), p=0.02) and for irisin (OR = 5.05, 95% CI= (1.14, 22.40), p=0.03) (Table 3). The gene discussed is FNDC5; the disease is cancer.