A study using activating FcR-deficient mice demonstrated that the anti-tumor activity of the anti-PD-L1 antibody clone 10F.9G2, the same used in this study, is partly dependent on FcR-mediated ADCC.57 The same study showed that the rat IgG2b isotype antibody, the same isotype of the anti-PD-L1 and the IgG used in this study, can interact with all mouse FcR,57 supporting our hypothesis. The gene discussed is CD274; the disease is neoplasm.