CD274 and neoplasm: Depletion of both CD8+ T and NK cells simultaneously further reduced therapeutic efficacy as compared with CD8+ T (p<0.05) or NK (p<0.0001) cell-depleted groups (figure 4C), demonstrating a causal role of both immune cell subsets in the RT+L19–IL2+anti-PD-L1 anti-tumor effect, with a major role by CD8+ T cells (p<0.01).