The conclusions of this study are two-fold: (a) RT synergizes better with tumor targeted-IL-2 than with ICB to elicit anti-tumor responses, thus patients not responding to ICB might benefit from other types of immunotherapy, and (b) combining ICB with other immunomodulating agents, both systemic and local, holds a great promise of increasing response rate to immunotherapies by turning cold into hot tumors and inducing durable disease control. The gene discussed is IL2; the disease is neoplasm.