Eleven of the 27 salivary cytokines, such as eotaxin, interleukin 5 (IL-5), MIP-1β, gamma interferon (IFN-γ), basic fibroblast growth factor (FGF), and Granulocyte colony-stimulating factor (G-CSF) altered early, within 72 h from baseline (i.e., at the SoH stage), yet did not exhibit any significant difference from baseline at later time points when gingivitis had developed (e.g., day 28, when the most severe gingivitis states were seen). The gene discussed is CSF3; the disease is gingivitis.