LMNA and Hutchinson-Gilford progeria syndrome: As it has recently been appreciated that Lamin A and the nuclear lamina play an important role in mediating transfer of information from the cytoplasm to the nucleus, the altered nuclear structure due the presence of progerin in HGPS may hinder or promote transfer of this information across the nuclear boundary, leading to deregulated gene expression (Kelley et al, 2011; Wilson, 2018).