Although we show that LOX levels are not increased in other SMC-containing tissues in HGPS mice (i.e., bladder and intestine), it would be of interest to evaluate LOX and miR-145 expression levels in non–SMC-containing tissues such as the skin, which also displays abnormalities in HGPS (Gonzalo et al, 2016). The gene discussed is LOX; the disease is Hutchinson-Gilford progeria syndrome.