Interestingly, both ANGPT2, which increases vascular permeability [61], and its antagonist ANGPT1 [62, 63] were increased in mastocytosis patients compared to HC [ANGPT1: (1,538 ± 2,136) vs (39.93 ± 45.60 pg/mL)] [ANGPT2: (1,492 ± 976) vs (1,085 ± 607) pg/mL] (Fig. 1b, c). This evidence concerns the gene ANGPT2 and mastocytosis.