(A) Decreased expression of HIST1H1B, a histone protein (B) increased expression of ACTA2, a marker of renal fibrosis, (C) decreased expression of NCLN, a part of the endoplasmic reticulum, and (D) decreased expression of CISD2, which is involved in mitochondrial autophagy. The gene discussed is ACTA2; the disease is renal fibrosis.