HSV-1 increases the hyperphosphorylation of tau protein,already present in AD patients, mainly at serine–proline (serine214 or S214 specific for AD) and threonine–proline (threonine212 or T212 specific for AD) motifs (Figure 3) as shown from the immunohistochemistrywork performed on SHSY-5Y cells by Wozniak et al. S214 and T212 aresites where hyperphosphorylated tau is common in AD.65 This evidence concerns the gene MAPT and Alzheimer disease.