Although association of seminal levels of SIRT1 andSIRT3 with male infertility at this point is unclear, theresults of this study suggest that low SIRT1 and SIRT3protein levelsin seminal plasma correlate with a highconcentration of ROS andabnormal morphology andmotility of sperms in asthenoteratozoospermia. Here, SIRT1 is linked to male infertility.