However, the relationship between SIRT1 andSIRT3, especially, with oxidative stressin the semen andmale infertility is largely unclear.Considering the antioxidant roles of SIRT1 and SIRT3, we hypothesizedthat SIRT1 and SIRT3 may play a contributory role inthe ROS damage (lipid peroxidation, and DNA fragmentation) of sperms, and the aim of this study was todetermine the association of SIRT1 and SIRT3 expression with oxidative stress, lipid peroxidation, and DNAfragmentation in asthenoteratozoospermia compared tonormozoospermia. The gene discussed is SIRT1; the disease is Infertility.