On the other side, the expression of Bcl-2 was significantlyelevated in these patients indicating a low rate of apoptosis in their ovarian cysts.Likewise, Isobe and Yoshimura (38) showed that the expressions of caspase-3 and BAX wassignificantly reduced in bovine cystic ovarian disease. The gene discussed is CASP3; the disease is Ovarian cyst.