PGR and neoplasm: Thereceptor of vitD is a nuclear receptor which is activated by 1, 25(OH)2D3 , resulting in modulation of the transcription rate of target gene (likecell growth and division genes and estrogen and progesterone receptors encoding genes) (31).These functions are the orgin of anti-tumor effects of 1,25(OH)2 D3 onuterine fibroid.