NLN and brain infarction: In a stroke setting, pharmacological inhibition of Nln after ischemia was accompanied by aggravated outcomes (brain infarction, edema formation, BBB impairment, and neuroinflammation) and elevated levels of all three peptides, whereas viral vector‐driven upregulation of Nln before stroke was associated with cerebroprotection and decreased levels of bradykinin, substance P, and neurotensin (Jayaraman et al., 2020; Karamyan, 2021).