First, although the mRNA and protein expression of PSMD7 in HNSCC and relative normal tissues were validated based on data from multiple public databases, further experiments are needed to uncover the protein expression profiles of PSMD7 in HNSCC and molecular mechanisms associated with how PSMD7 regulates growth of tumor cell and tumor-infiltrating cells to influence the prognosis of HNSCC patients. Here, PSMD7 is linked to head and neck squamous cell carcinoma.