Compared with participants without metabolic syndrome, those with metabolic syndrome were older and had higher values for urinary ACR, eGFR, BMI, WC, SBP, DBP, TG, FPG, fasting insulin, γ-GGT, and HOMA-IR as well as a lower HDL-C level (all P<0.001). The gene discussed is INS; the disease is metabolic syndrome.