After adjustment for age, sex, BMI, physical activity, smoking status, drinking status, γ-GGT, fasting insulin, eGFR, and ACR, the ORs and 95% Cis the associations of metabolic syndrome with low-grade albuminuria and CKD were 1.30 (1.05–1.61) and 1.71 (1.20–2.44), respectively. The gene discussed is INS; the disease is metabolic syndrome.