Furthermore, a study showed consistent results with our study, where the glioma cell-derived EVs increased the long intergenic non-coding RNA CCAT2 (linc-CCAT2) expression in human umbilical vein endothelial cells (HUVECs), and the glioma cell-derived EVs containing linc-CCAT2 enhanced HUVEC angiogenesis and inhibited HUVEC apoptosis [36]. This evidence concerns the gene CCAT2 and central nervous system cancer.