Congenital X-linked mutations in CYBB, which encoding the gp91 (phox) subunit of the phagocyte NADPH oxidase, could lead to recurrent tuberculosis in patients with defects preferentially manifest in macrophages, suggesting CYBB is associated with mendelian susceptibility to mycobacterial disease and the respiratory burst in human macrophages is a crucial mechanism for protective immunity to tuberculous mycobacteria [28, 29]. Here, CYBB is linked to tuberculosis.