TIMP1 and type 2 diabetes mellitus: As shown in Figure 2, the mean levels of ANG-1 (334.62 ng/ml), PDGF-BB (37.86 pg/ml), TIMP-1 (7.39 ng/ml), and VEGFR2 (12.47 ng/ml) in the DME group were significantly higher than those in the T2DM group (268.94 ng/ml, 28.60 pg/ml, 6.27 ng/ml, and 10.71 ng/ml), respectively (p < 0.001).