The major advantage of the research was firstly evaluate the associations of KATP mutations with the risk of increased Apo B concentration (≥ 80 mg/dL) and ASCVD in South China, and characterize the circulating expression profile of exo-miRs under interplay status between genetic (KATP variants) and environmental (elevated Apo B serum levels) factors, intimating that the possible epigenetic modification effect of exo-miRs in development of dyslipidemia and its related atherosclerotic vascular events. The gene discussed is APOB; the disease is atherosclerosis.