APOB and atherosclerosis: The major disadvantages of the study were as follows: Firstly, due to the sample size (N=1044), large-scale subgroup analysis based on Apo B serum level (< 80 mg/dL vs. ≥ 80 mg/dL) and genotypes (GG vs. AA + GA) of KATP rs11046182 will help to further verify the hypothesis that the occurrence and development of increased Apo B serum concentration and its related ASCVD arises from complex interaction between genetic and environment factors.