Severity criteria were documented in 15/17 (88.2%) severe patients in 2016-2017: the most frequent were thrombocytopenia/bleeding (9/15, 60% severe forms); AST/ALT > 1,000 UI/L (7/15, 47% severe forms); And acute hepatitis (7/15, 47% severe forms) (Supplementary figure 1). The gene discussed is GPT; the disease is Acute hepatitis.