Although AM and MM fundamentally differ from nonacral CM in their pathogenesis and therapeutic targets,27 further studies should include investigation of mechanisms other than mutational burden that can be influenced extrinsically, including factors such as obesity and differential composition of the gut microbiome, for their potential contribution to differential immune responses and efficacy of anti‐PD‐1 in these rare melanoma subtypes. The gene discussed is PDCD1; the disease is obesity disorder.